Impact of hepatitis C coinfection on cognitive outcomes in HIV-infected individuals

摘要: Hepatitis C virus (HCV) infection has emerged as an important factor in determining the presence and severity of cognitive impairment among individuals infected with HIV. Studies have demonstrated that coinfected patients perform worse on neuropsychological testing than monoinfected patients, typically tests processing speed, psychomotor learning efficiency. The mechanisms associated this increased not been identified, though a number candidates proposed. This review summarizes current literature HIV-HCV coinfection describes possible mediating relationship. Special emphasis is placed HCV brain concomitant liver disease primary factors may drive population. article concludes suggestions for further research are aimed toward more fully defining neural substrates patients.