Sulfate radicals enable a non-enzymatic Krebs cycle precursor.
作者： Markus A. Keller , Domen Kampjut , Stuart A. Harrison , Markus Ralser
关键词: Sulfate radicals 、 Glyoxylate cycle 、 Biochemistry 、 Sulfate 、 Carbon 、 Catalysis 、 Peroxydisulfate 、 Chemistry 、 Citric acid cycle 、 Organic chemistry 、 Succinic semialdehyde
摘要: The evolutionary origins of the Krebs cycle (tricarboxylic acid cycle) are not currently clear. Despite the existence of a simple non-enzymatic Krebs cycle catalyst being dismissed only a few years ago as 'an appeal to magic', citrate and other intermediates have since been discovered on a carbonaceous meteorite and do interconvert non-enzymatically. To identify a metabolism-like non-enzymatic Krebs cycle catalyst, we used combinatorial, quantitative high-throughput metabolomics to systematically screen iron and sulfate compounds in a …
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