Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factor.
作者： Uwe Ernsberger , Michael Sendtner , Hermann Rohrer
DOI: 10.1016/0896-6273(89)90312-7
关键词: Sympathetic ganglion 、 Biology 、 Endocrinology 、 Nerve growth factor 、 Ciliary neurotrophic factor 、 Tyrosine hydroxylase 、 Internal medicine 、 Population 、 Embryonic stem cell 、 Vasoactive intestinal peptide 、 Cellular differentiation
摘要: At early developmental stages (embryonic day 7, E7), chick paravertebral sympathetic ganglia contain a cell population that divides in culture while expressing various neuronal properties. In an attempt to identify factors control proliferation, we found ciliary neurotrophic factor (CNTF) specifically inhibits the proliferation of those cells markers. addition, CNTF affects differentiation ganglion by inducing expression vasoactive intestinal peptide immunoreactivity (VIP-IR). After 1 culture, tyrosine hydroxylase (TH-IR) was expressed about 86% whereas VIP-IR virtually absent. presence CNTF, 50%-60% after 4 days culture; however, none absence CNTF. These results, and demonstration express both VIP TH-IR, indicate is induced initially hydroxylase. The findings suggest potential role for as affecting developing neurons.
sci-hub.se 参考文章(46)
ALAN M. COHEN, DNA SYNTHESIS AND CELL DIVISION IN DIFFERENTIATING AVIAN ADRENERGIC NEUROBLASTS Dynamics of Degeneration and Growth in Neurons#R##N#Proceedings of the International Symposium Held in Wenner–Gren Center, Stockholm, May 1973. pp. 359- 370 ,(1974) , 10.1016/B978-0-08-017917-9.50033-0
V Hamburger, JK Brunso-Bechtold, JW Yip, Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor. The Journal of Neuroscience. ,vol. 1, pp. 60- 71 ,(1981) , 10.1523/JNEUROSCI.01-01-00060.1981
H Rohrer, I Sommer, Simultaneous expression of neuronal and glial properties by chick ciliary ganglion cells during development The Journal of Neuroscience. ,vol. 3, pp. 1683- 1693 ,(1983) , 10.1523/JNEUROSCI.03-08-01683.1983
Y.A. Barde, D. Edgar, H. Thoenen, Purification of a new neurotrophic factor from mammalian brain. The EMBO Journal. ,vol. 1, pp. 549- 553 ,(1982) , 10.1002/J.1460-2075.1982.TB01207.X
GD Maxwell, PD Sietz, PH Chenard, Development of somatostatin-like immunoreactivity in embryonic sympathetic ganglia. The Journal of Neuroscience. ,vol. 4, pp. 576- 584 ,(1984) , 10.1523/JNEUROSCI.04-02-00576.1984
AJ Doupe, SC Landis, PH Patterson, Environmental influences in the development of neural crest derivatives: glucocorticoids, growth factors, and chromaffin cell plasticity The Journal of Neuroscience. ,vol. 5, pp. 2119- 2142 ,(1985) , 10.1523/JNEUROSCI.05-08-02119.1985
H. Rohrer, S. Henke-Fahle, T. El-Sharkawy, H.D. Lux, H. Thoenen, Progenitor cells from embryonic chick dorsal root ganglia differentiate in vitro to neurons: biochemical and electrophysiological evidence. The EMBO Journal. ,vol. 4, pp. 1709- 1714 ,(1985) , 10.1002/J.1460-2075.1985.TB03840.X
JE Garcia-Arraras, M Chanconie, J Fontaine-Perus, In vivo and in vitro development of somatostatin-like-immunoreactivity in the peripheral nervous system of quail embryos The Journal of Neuroscience. ,vol. 4, pp. 1549- 1558 ,(1984) , 10.1523/JNEUROSCI.04-06-01549.1984
ML Yodlowski, JR Fredieu, SC Landis, Neonatal 6-hydroxydopamine treatment eliminates cholinergic sympathetic innervation and induces sensory sprouting in rat sweat glands The Journal of Neuroscience. ,vol. 4, pp. 1535- 1548 ,(1984) , 10.1523/JNEUROSCI.04-06-01535.1984
H. Rösner, M. Al-Aqtum, S. Henke-Fahle, Developmental expression of GD3 and polysialogangliosides in embryonic chicken nervous tissue reacting with monoclonal antiganglioside antibodies Developmental Brain Research. ,vol. 18, pp. 85- 95 ,(1985) , 10.1016/0165-3806(85)90252-4