Predictors of treatment failure, incipient hypothyroidism, and weight gain following radioiodine therapy for Graves' thyrotoxicosis.

摘要: Background: Following radioiodine (131I) therapy, both late recognition of hypothyroidism and treatment failure may result in adverse outcomes. Aim: We sought to assess indicators incipient following 131I determine factors predictive weight gain. Subjects methods: Retrospective study 288 patients receiving for Graves’ thyrotoxicosis. Primary outcome measures were thyroid status change at 1 yr 131I. Results: The rate was 13.5%. Hypothyroidism developed 80.9%, with 58.5% having levels free T4 (fT4) 6 pmol/l (p=0.05). main predictor gain fT4 level immediately prior treatment; those the lowest tertile gained a median 3.1 kg whilst highest 7.4 (median difference 4.3 kg; 95% confidence interval: 2.5–6.2). Conclusions: Marked is common often occurs early. Simple biochemical parameters help identify potentially limit excess Treatment severe thyrotoxicosis such cases larger doses be warranted.