Continuous Methimazole Therapy and Its Effect on the Cure Rate of Hyperthyroidism Using Radioactive Iodine: An Evaluation by a Randomized Trial

摘要: Background: A randomized clinical trial was performed to clarify whether continuous use of methimazole (MTZ) during radioiodine (131I) therapy influences the final outcome this therapy. Design: Consecutive patients with Graves’ disease (n = 30) or a toxic nodular goiter 45) were rendered euthyroid by MTZ and stop 8 d before 131I (−MTZ; n 36) continue until 4 wk after (+MTZ; 39). Calculation activity included an assessment half-life thyroid volume. Results: The 24-h uptake lower in +MTZ group than −MTZ (44.8 ± 15.6% vs. 62.1 9.9%, respectively; P < 0.001). At 3 therapy, no significant change serum free T4 index observed (109 106 83 28 nmol/liter at baseline; 0.26), contrasting increase (180 110 82 26 nmol/liter; number cured 17 (44%) 22 (61%) groups, respectively ...