作者: Peter A. Bron , Peter van Baarlen , Michiel Kleerebezem
DOI: 10.1038/NRMICRO2690
关键词: Gut flora 、 Intestinal mucosa 、 Immunology 、 Immune system 、 Biology 、 Microbiology 、 Effector 、 Probiotic 、 Antibiotic-associated diarrhea 、 Innate immune system 、 Bacteria
摘要: Probiotic bacteria can modulate immune responses in the host gastrointestinal tract to promote health. The genomics era has provided novel opportunities for the discovery and characterization of bacterial probiotic effector molecules that elicit specific responses in the intestinal system. Furthermore, nutrigenomic analyses of the response to probiotics have unravelled the signalling and immune response pathways which are modulated by probiotic bacteria. Together, these genomic approaches and nutrigenomic analyses have identified …