Catalytic, enantioselective acetate aldol additions to α,β-ynals: Preparation of optically active propargylic alcohols
作者： Robert A. Singer , Mary S. Shepard , Erick M. Carreira
DOI: 10.1016/S0040-4020(98)00344-5
关键词: Aldol reaction 、 Addition reaction 、 Organic chemistry 、 Catalysis 、 Chemistry 、 Enantioselective synthesis 、 Silylation 、 Optically active 、 Ketene
摘要: Abstract A catalytic, enantioselective acetate-aldol addition reaction of silyl ketene acetals with α,β-ynals and 3 mol % a chiral Ti(IV) complex is described. This process provides access to optically active β-hydroxy-γ-alkynyl esters in 84–96% yields 94–97% ee's.
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