Axonal transport defects: a common theme in neurodegenerative diseases.

摘要: A core pathology central to most neurodegenerative diseases is the misfolding, fibrillization and aggregation of disease proteins form hallmark lesions specific disorders. The mechanisms underlying these brain-specific amyloidoses are focus intense investigation defective axonal transport has been hypothesized play a mechanistic role in several disorders; however, this hypothesis not extensively examined. Discoveries mutations human genes encoding motor responsible for do provide direct evidence involvement diseases, supported by studies animal models neurodegeneration. In review, we summarize recent findings related Focusing on from neuropathologic perspective, highlight discoveries protein some as well illustrate new insights We also review current understanding biology including major slow transport.