Early Acute Kidney Injury in Military Casualties

摘要: Abstract : While acute kidney injury (AKI) has been well studied in a variety of patient settings, there is paucity data patients injured the course recent wars Iraq and Afghanistan. We sought to establish rate early AKI this population define risk factors for its development. combined results two studies performed at combat support hospitals Only US service members who required care intensive unit were included analysis. Data on age, race, sex, Injury Severity Score (ISS), first available lactate, requirement massive transfusion collected. Univariate analyses identify associated with subsequent development AKI. Multivariable Cox regression was used adjust potential confounders. The observational cohorts yielded 134 subjects had broadly similar populations but differed terms age need transfusion. cohort 34.3%, majority (80.5%) occurring within hospital days. Patients higher unadjusted mortality rates than those without (21.7% vs. 2.3%, p less 0.001). After adjustment, ISS (hazard ratio, 1.02; 95% confidence interval, 1.00 - 1.03; = 0.046) initial lactate 1.16; 1.03--1.31; 0.015) independently common casualties enrolled prospective studies, crude mortality. are