Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients
作者： Azra Bihorac , Matthew J. Delano , Jesse D. Schold , Maria Cecilia Lopez , Avery B. Nathens
DOI: 10.1097/SLA.0B013E3181DEB6BC
关键词:
摘要: OBJECTIVE: To determine clinical and genomic characteristics in-hospital mortality risk associated with acute kidney injury (AKI) in the multicenter prospective cohort of patients blunt trauma. SUMMARY BACKGROUND DATA: Less severe stages AKI characterized by small changes serum creatinine (sCr) are inadequately studied among trauma patients. METHODS: We performed a secondary analysis "Inflammation Host Response to Injury" (Glue Grant) database include adult without history disease. was defined Risk, Injury, Failure, Loss, End-stage Kidney (RIFLE) classification, which requires 50% increase sCr stratifies into following 3 severity stages: risk, injury, failure. Association between all analyzed using multivariable logistic regression analysis. Genome-wide expression on whole blood leukocytes obtained within 12 hours RESULTS: occurred 26% 982 The adjusted for hospital death times higher compared (odds ratio = 3.05) (95% confidence interval, 1.73-5.40). This evident dose-response manner even mild had odds dying 2.57 1.19-5.50) AKI. failed show significant number genes whose could discriminate CONCLUSIONS: In patients, an independent death. Language: en
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