Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa.
作者： Phurpa Wangchuk , Paul A. Keller , Stephen G. Pyne , Thanapat Sastraruji , Malai Taweechotipatr
DOI: 10.1177/1934578X1200700507
关键词: Biological activity 、 Isoquinoline 、 Lead compound 、 Anti-inflammatory 、 Bicuculline 、 Traditional medicine 、 Phytochemical 、 Biology 、 Corydalis 、 Botany 、 Protopine
摘要: The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. phytochemical study resulted in isolation nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) bicuculline (9), with complete NMR data 2 3 provided here Crude extracts exhibitedsignificant anti-inflammatory (p < 0.01) activity against TNF-alpha production LPS activated THP-1 cells. acetylcholinesterase inhibitory compounds 2, 4 7 antiplasmodial compound 5 P. falciparum strains TM4/8.2 K1CB1 (multidrug resistant strain) are reported Stylopine (4) did not show antimalarial strain contrast to a previous report. This generated scientific basis use this plant Bhutanese traditional medicine, either individually or combination other medicinal ingredients treat broad range disorders. also identified as potential new lead compound.
sagepub.com
sci-hub.se 参考文章(39)
Ki Hun Park, Tae Joung Ha, Eun Kyoung Seo, Min Suk Yang, Seon Woo Hwang, Sang Hae Nam, Mi Yae Shon, Dae Sik Jang, Jun Lee, Cytotoxic Isoquinoline Alkaloids from Chelidonium majus var. asiaticum Journal of Applied Biological Chemistry. ,vol. 48, pp. 198- 201 ,(2005)
Geoffrey A. Cordell, I. W. Southon, J. Buckingham, Dictionary of alkaloids Chapman and Hall. ,(1989)
J. Buckingham, Dictionary of natural products ,(2014)
N.S. Narasimhan, R.S. Mali, B.K. Kulkarni, Synthetic application of lithiation reactions-XVI : syntheses of (±) tetrahydropalmatine, (±) canadine, (±) stylopine and (±) sinactine Tetrahedron. ,vol. 39, pp. 1975- 1982 ,(1983) , 10.1016/S0040-4020(01)91915-5
R. Verpoorte, Th. Mulder-Krieger, M.J. Verzijl, J.M. Verzijl, A.Baerheim Svendsen, High-performance liquid chromatography of Cinchona alkaloids Journal of Chromatography A. ,vol. 261, pp. 172- 175 ,(1983) , 10.1016/S0021-9673(01)87937-1
R. H. F. Manske, R. Rodrigo, D. B. MacLean, D. E. F. Gracey, J. K. Saunders, Structure of sibiricine, an alkaloid of Corydalissibirica Canadian Journal of Chemistry. ,vol. 47, pp. 3585- 3588 ,(1969) , 10.1139/V69-592
Malai Taweechotipatr, Chandra Iyer, Jennifer K. Spinler, James Versalovic, Somying Tumwasorn, Lactobacillus saerimneri and Lactobacillus ruminis: novel human-derived probiotic strains with immunomodulatory activities. Fems Microbiology Letters. ,vol. 293, pp. 65- 72 ,(2009) , 10.1111/J.1574-6968.2009.01506.X
Ghulam N Shah, Asif Zaman, Mushtaq A Khan, Alesander I Gray, Gordon J Provan, Peter G Waterman, Ian H Sadler, None, (±)-Severzinine from Corydalis flabellats: Interpretation of NMR Spectra Journal of Natural Products. ,vol. 52, pp. 1027- 1031 ,(1989) , 10.1021/NP50065A018
A. Radcliffe-Smith, A. J. C. Grierson, D. G. Long, Flora of Bhutan : including a record of plants from Sikkim Kew Bulletin. ,vol. 41, pp. 231- ,(1986) , 10.2307/4103047
Walter Majak, Yili Bai, Michael H Benn, Phenolic amides and isoquinoline alkaloids from Corydalis sempervirens Biochemical Systematics and Ecology. ,vol. 31, pp. 649- 651 ,(2003) , 10.1016/S0305-1978(02)00225-9