TP53mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours
作者： Tatiana Nedelko , Volker M. Arlt , David H. Phillips , Monica Hollstein
DOI: 10.1002/IJC.24006
关键词: Cancer research 、 Aristolochic acid 、 Mutation 、 Aristolochia 、 Cancer 、 Molecular genetics 、 Mutagen 、 Genetics 、 Carcinogenesis 、 Genotype 、 Biology 、 Oncology
摘要: The proposal has been put forward that the primary cause of Balkan endemic nephropathy (BEN) is exposure to food crops contaminated with seeds Aristolochia spp, which contain high levels aristolochic acids (AA). Recently, tumour DNA samples from patients BEN were found harbour principally A T mutations in TP53 suppressor gene (Grollman et al., Proc Natl Acad Sci USA 2007;104:12129-34). Using a novel mutation assay we can induce and select human sequences vitro by cultured cells mutagen, elicited acid at sites rarely mutated cancers general, but observed patients. This concordance specific patient tumours I-exposed cultures supports argument AA direct role aetiology BEN-associated cancer.
core.ac.uk
cabdirect.org
sci-hub.se 参考文章(18)
Graham M. Lord, Monica Hollstein, Volker M. Arlt, Candice Roufosse, Charles D. Pusey, Terry Cook, Heinz H. Schmeiser, DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy American Journal of Kidney Diseases. ,vol. 43, pp. e18.1- e18.7 ,(2004) , 10.1053/J.AJKD.2003.11.024
Marie Stiborová, Eva Frei, Volker M. Arlt, Heinz H. Schmeiser, Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy. Mutation Research-reviews in Mutation Research. ,vol. 658, pp. 55- 67 ,(2008) , 10.1016/J.MRREV.2007.07.003
N. Feldmeyer, H.H. Schmeiser, K.-R. Muehlbauer, D. Belharazem, Y. Knyazev, T. Nedelko, M. Hollstein, Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 608, pp. 163- 168 ,(2006) , 10.1016/J.MRGENTOX.2006.02.017
Audrey Petitjean, Ewy Mathe, Shunsuke Kato, Chikashi Ishioka, Sean V. Tavtigian, Pierre Hainaut, Magali Olivier, Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Human Mutation. ,vol. 28, pp. 622- 629 ,(2007) , 10.1002/HUMU.20495
Shunsuke Kato, Shuang-Yin Han, Wen Liu, Kazunori Otsuka, Hiroyuki Shibata, Ryunosuke Kanamaru, Chikashi Ishioka, None, Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 8424- 8429 ,(2003) , 10.1073/PNAS.1431692100
E C Pietsch, O Humbey, M E Murphy, Polymorphisms in the p53 pathway. Oncogene. ,vol. 25, pp. 1602- 1611 ,(2006) , 10.1038/SJ.ONC.1209367
Nieves Palma, Serena Cinelli, Orazio Sapora, Samuel H. Wilson, Eugenia Dogliotti, Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress. Chemical Research in Toxicology. ,vol. 20, pp. 1031- 1037 ,(2007) , 10.1021/TX700027J
Magali Olivier, Ros Eeles, Monica Hollstein, Mohammed A. Khan, Curtis C. Harris, Pierre Hainaut, The IARC TP53 database: new online mutation analysis and recommendations to users. Human Mutation. ,vol. 19, pp. 607- 614 ,(2002) , 10.1002/HUMU.10081
Z. Liu, M. Hergenhahn, H. H. Schmeiser, G. N. Wogan, A. Hong, M. Hollstein, Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 2963- 2968 ,(2004) , 10.1073/PNAS.0308607101
M Reinbold, J-L Luo, T Nedelko, B Jerchow, M E Murphy, C Whibley, Q Wei, M Hollstein, Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72 Oncogene. ,vol. 27, pp. 2788- 2794 ,(2008) , 10.1038/SJ.ONC.1210932