Porphyran capped gold nanoparticles as a novel carrier for delivery of anticancer drug: In vitro cytotoxicity study
作者： Vinod Venkatpurwar , Anjali Shiras , Varsha Pokharkar , None
DOI: 10.1016/J.IJPHARM.2011.02.054
关键词: Drug delivery 、 Nuclear chemistry 、 Drug carrier 、 Nanoparticle 、 Zeta potential 、 Chloroauric acid 、 Stereochemistry 、 Colloidal gold 、 Chemistry 、 Porphyran 、 Microparticle
摘要: In the present study, we have explored porphyran as a reducing agent for one pot size controlled green synthesis of gold nanoparticles (AuNps) and further investigated its application carrier delivery an anticancer drug. The prepared AuNps showed surface plasmon resonance centered at 520 nm with average particle 13±5 nm. FTIR spectra suggested that sulfate moiety is mainly responsible reduction chloroauric acid. capping was evident from negative zeta potential value electrostatic stability. Thus, acts well agent. These are highly stable in wide range pH electrolyte concentration. Porphyran capped exhibited enhanced cytotoxicity on human glioma cell line (LN-229) compared to native porphyran. Consequently, these been utilized drug doxorubicin hydrochloride (DOX). Spectroscopic examination revealed DOX conjugated onto via hydrogen bonding. release loaded found be sixfold higher acetate buffer (pH 4.5) physiological 7.4). Further, demonstrated LN-229 equal dose solution. This established delivery.
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