BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF.
作者： H. H. Pulkkinen , M. Kiema , J. P. Lappalainen , A. Toropainen , M. Beter
DOI: 10.1007/S10456-020-09748-4
关键词: Chemistry 、 Signal transduction 、 Kinase insert domain receptor 、 Vascular endothelial growth factor 、 Hippo signaling 、 Cell biology 、 Angiogenesis 、 Hippo signaling pathway 、 Notch signaling pathway 、 Bone morphogenetic protein
摘要: The BMP/TGFβ-Smad, Notch and VEGF signaling guides formation of endothelial tip stalk cells. However, the crosstalk bone morphogenetic proteins (BMPs) vascular growth factor receptor 2 (VEGFR2) has remained largely unknown. We demonstrate that BMP family members regulate VEGFR2 signaling, act via TAZ-Hippo pathway. BMPs were found to be regulated after gene transfer in C57/Bl6 mice a porcine myocardial ischemia model. 2/4/6 identified as endothelium-specific targets VEGF. BMP2 modulated VEGF-mediated sprouting Delta like Canonical Ligand 4 (DLL4). BMP6 by regulating expression acted Hippo effector TAZ, known cell survival/proliferation, dysregulated cancer. In matrigel plug assay nude was further demonstrated induce angiogenesis. is first member directly both neovessel formation. It may thus serve target pro/anti-angiogenic therapies.
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