Oral cyclosporine A--the current picture of its liposomal and other delivery systems.

摘要: The discovery of cyclosporine A was a milestone in organ transplantation and the treatment autoimmune diseases. However, developing an efficient oral delivery system for this drug is complicated by its poor biopharmaceutical characteristics (low solubility permeability) need to carefully monitor levels blood. Current research exploring various approaches, including those based on emulsions, microspheres, nanoparticles, liposomes. Although progress has been made, none formulations flawless. This review brief description main pharmaceutical systems devices that have described context physicochemical properties character interactions with lipid membranes.