Studies with a dual-beam thermospray interface in high-performance liquid chromatography—mass spectrometry

摘要: Abstract A dual-beam thermospray (TSP) interface has been constructed to provide a mode of ionization which is almost independent the operating conditions for high-performance liquid chromatography. In this interface, one capillary used vaporization eluate, i.e., sample solution while other provides reagent ions ion formation by an appropriate electrolyte solution. Accordingly, mass spectra are obtained from compounds dissolved in electrolyte-free non-aqueous mobile phase. For water-soluble technique yields slightly higher sensitivity and lower level fragmentation than conventional single-beam TSP technique. optimization efficiency, setting vaporizer temperature much less critical interface. The compatibility with low phase flow-rates as typical microbore columns also demonstrated.