Chapter 2. Ionisation Methods in LC-MS and LC-MS-MS (TSP, APCI, ESP and cf-FAB)

摘要: Publisher Summary This chapter discusses the ionization methods and processes used in liquid chromatography–mass spectrometry (LC–MS). The understanding of these is a qualitative nature sometimes still matter debate. knowledge accumulated so far provides means to priori judge effectiveness certain with respect solution analytic problems. A basic leads better control experimental possibilities LC–MS rationalized approach method development. emphasizes small compounds because most pesticides and, even their metabolites, have molecular weights below 1,000 amu. also gas-phase chemical process, which operative various methods, ion evaporation contributes different methods.