Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides.

摘要: The EtOH extract of gardenia (Gardenia jasminoides Ellis) fruits was previously found to possess potent anti-angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay. Bioassay-guided fractionation and purification yielded an active compound, which determined be iridoid glucoside, geniposide, by spectral analyses. Geniposide showed a dose-dependent manner. It also exhibited inhibitory effect range 25-100 microM on growth transformed NIH3T3 cell line.