Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis
作者： Gioacchino Calapai , Francesco Corica , Andrea Corsonello , Lidia Sautebin , Massimo Di Rosa
DOI: 10.1172/JCI5867
关键词: Metabolism 、 Leptin 、 Serotonin 、 Arginine 、 Nitric oxide synthase 、 Weight gain 、 Internal medicine 、 Diencephalon 、 Nitroarginine 、 Chemistry 、 Endocrinology
摘要: Leptin administration inhibits diencephalic nitric oxide synthase (NOS) activity and increases brain serotonin (5-HT) metabolism in mice. We evaluated food intake, body-weight gain, NOS activity, content of tryptophan (TRP), 5-HT, hydroxyindoleacetic acid (5-HIAA), 5-HIAA/5-HT ratio after intracerebroventricular (ICV) or intraperitoneal (IP) leptin injection Five consecutive days ICV IP injections induced a significant reduction neuronal (nNOS) caused dose-dependent increase 5-HIAA, the ratio. Diencephalic 5-HT showed 3 hours single injection. This effect was maintained for had disappeared by 12 After injection, peak achieved at 6 hours. Single significantly increased content. Leptin-induced antagonized coadministration L-arginine only when latter injected, whereas D-arginine did not influence effects on Finally, nNOS-knockout mice, appetite-suppressant strongly reduced, leptin-induced completely abolished. Our results indicate that L-arginine/NO pathway is involved mediating feeding behavior, demonstrate nNOS required turnover.
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