Mechanisms linking depression co-morbid with obesity: An approach for serotonergic type 3 receptor antagonist as novel therapeutic intervention

摘要: Despite of the enormous research, therapeutic treatment for depression has always been a serious issue. Even though and obesity are individual abnormal health conditions, each act as triggering factor other. Obese individuals twice prone to develop than that non-obese persons. The exact mechanism how increases risk still remains an area interest research in neuropsychopharmacology. Depression share some common pathological pathways such hyperactivity hypothalamic-pituitary-adrenal (HPA) axis, dysregulation oxidant/antioxidant system balance, higher level inflammatory cytokines, leptin resistance, altered plasma glucose, insulin reduced neuronal brain derived neurotrophic (BDNF) decreased serotonergic neurotransmission various regions brain. antidepressant-like effect 5-HT3 receptor antagonists through allosteric modulation is well evident from several investigations belonging our other laboratories. Furthermore, serotonin regulates diet intake, leptin, corticosterone, mechanisms, resistance BDNF concentration present review deals with biological mechanisms involved co-morbid by target disorder.