Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence.
作者： Jurandir F Comar , Francielli M de S Silva-Comar , Roberto K N Cuman , Stefânia N Lavorato , Roseli B de Lacerda
DOI: 10.3390/PH14020148
关键词:
摘要: Serotonin (5-HT) receptors are found throughout central and peripheral nervous systems, mainly in brain regions involved the neurobiology of anxiety depression. 5-HT currently promising targets for discovering new drugs treating disorders ranging from migraine to neuropsychiatric upsets, such as It is well described current literature that expresses seven types comprising eighteen distinct subtypes. In this article, we comprehensively reviewed 5-HT1-7 receptors. Of known today, thirteen G protein-coupled (GPCRs) represent approximately 40% used humans. Signaling pathways related these play a crucial role neurodevelopment can be modulated develop effective therapies treat This review presents experimental evidence modulation "serotonergic receptosome" treatment depression, demonstrating state-of-the-art research phytochemicals disorders. addition, detailed aspects pharmacological mechanism action all receptor families were reviewed. From review, it will possible direct rational design towards involve signaling via
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