Cotranslational folding of proteins.
作者： M. A. Basharov
关键词: Protein folding 、 Chaperone (protein) 、 Bioorganic chemistry 、 Phi value analysis 、 Biophysics 、 Chromosomal translocation 、 Biochemistry 、 Ribosome 、 Protein translocation 、 Elongation 、 Biology
摘要: We suppose that folding of proteins occurs cotranslationally by the following scheme. The polypeptide chains enter sites from protein translocation complexes (ribosome, machinery incorporated in membranes) directionally with N-terminus and gradually. chain starts to fold as soon its N-terminal residue enters site complex. process accompanies is completed after C-terminal leaves Proteins sequential stages, their into compartments. At each stage a particular conformation part has emerged complex formed. formation both conformations segment at final native last time does not exceed duration fastest elongation cycle on ribosome.
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