The relationship between synonymous codon usage and protein structure in Escherichia coli and Homo sapiens

作者: Wanjun Gu , Tong Zhou , Jianmin Ma , Xiao Sun , Zuhong Lu

DOI: 10.1016/J.BIOSYSTEMS.2003.10.001

关键词: Structural Classification of Proteins databaseGeneticsSynonymous substitutionCodon usage biasStart codonBiologySilent mutationHomo sapiensGC-contentProtein structure

摘要: The role of silent position in the codon on protein structure is an interesting and yet unclear problem. In this paper, 563 Homo sapiens genes 417 Escherichia coli coding for proteins with four different folding types have been analyzed using variance analysis, a multivariate analysis method newly used usage to find correlation between amino acid composition, synonymous codon, organisms. It has found that E. coli, both compositions differently folded gene classes are significantly different. was also only composition H. sapiens. There no universal these two Further shown GC content second can distinguish

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