MicroRNA regulation of immune events at conception.

摘要: The reproductive tract environment at conception programs the developmental trajectory of embryo, sets course pregnancy, and impacts offspring phenotype health. Despite fundamental importance this stage reproduction, rate-limiting regulatory mechanisms operating locally to control fertility fecundity are incompletely understood. Emerging studies highlight roles for microRNAs (miRNAs) in regulating processes modulating quality strength female immune response. Since endometrial receptivity robust placentation require specific adaptation response, we hypothesize that miRNAs participate establishing pregnancy through effects on key gene networks cells. Our recent investigated induced peri-conception environment, focusing have immune-regulatory roles-particularly miR-223, miR-155, miR-146a. Genetic mouse models deficient individual proving informative defining these generation stabilization T cells (Treg cells) confer adaptive tolerance. Overlapping redundant functions between target multiple genes, combined with targeting indicate complex sensitive networks. Although date most data miRNA regulation events from mice, conserved across species imply similar biological pathways operate all mammals. Understanding response will advance our knowledge how environmental determinants act conception, could practical applications animal breeding as well human fertility.