作者： P. Berchialla , G. Migliaretti , D. Gregori , A. Borraccino , Commissione Gh Piemonte
DOI:
关键词: Regression analysis 、 Medicine 、 GH Deficiency 、 Growth curve (biology) 、 Percentile 、 Gh treatment 、 Pediatrics 、 Demography
摘要: Intheliterature,fewstudiesanalyzetheeffectof GH therapyon height,preferringa more indirectapproach, where factors influencing the total pubertal and pre-puber- tal growth in GH-deficient patients are evaluated sub- sequently used to estimate overall effect at end of therapy; unfortunately, this approach does not quantify real gain treated patients. Using a non-para- metric Empirical Bayes approach, our study analyzes growthresponsetoGHtreatmentinahomogeneouscohort 317 with pituitary deficiency who were en- rolled during their pre-pubertal stage Piedmont Registry (Italy), between January 2000-October 2008, haveatleast2yroffollow-up.Toestimatethegrowthcurve for males females, non-parametric regression model wasfitted,applyingEmpiricalBayestechniques.Avalidation ofthemodelwasalsoperformed.Improvementwasevident inbothgenders,sincebothmalesandfemalesmeangrowth curve, which started below 3rd percentile begin- ning therapy, reached 10th Tan- nercurveattheendofobservation(17yroldformalesand 14 yr old females); estimation procedure achieved goodprecision.Themethodologicalapproachallowsforfit- tingamodelabletoevaluatelongitudinallytheresponseto treatment, by means estimating curve,eveninpresenceofsparseinformationaboutchildren heights. (J. Endocrinol. Invest. 35: 209-214, 2012) ©2012, Editrice Kurtis