Mutagenic activity in the rivers Rhine and Meuse in The Netherlands
作者： C.F. van Kreijl , H.J. Kool , M. de Vries , H.J. van Kranen , E. de Greef
DOI: 10.1016/0048-9697(80)90004-2
关键词: Microsomal enzymes 、 Rat liver 、 Distilled water 、 River water 、 Human health 、 Ames test 、 Environmental chemistry 、 Chemistry 、 Environmental engineering 、 Waste Management and Disposal 、 Pollution
摘要: Abstract Several water samples of the rivers Rhine and Meuse have been tested for mutagenic activity in Ames Salmonella/microsome assay a fluctuation assay. Samples were taken at places where enter The Netherlands several downstream locations relevant to drinking supplies. For this included each river-branches Waal, Lek IJssel. Before testing, all concentrated by adsorption on XAD-resins subsequent elution with dimethylsulfoxide. results obtained clearly show that derived from river its branches contain activity. Positive test showing dose—response relations observed primarily strain TA 98 after metabolic activation (rat liver microsomal enzymes). In contrast this, little or no was detected Meuse. This indicated that, methods used, overall least 10 times below Rhine. assay, using same bacterial strains, concentrates could not be as such. However, appropriate dilution dimethylsulfoxide distilled water, proved about 10–15 more sensitive than test. significance these respect human health is briefly discussed.
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