Surface marker expression in adult acute myeloid leukaemia: correlations with initial characteristics, morphology and response to therapy.

摘要: The clinical significance of surface markers was investigated in 145 cases acute myeloid (AML) or undifferentiated leukaemia (AUL), using a panel six monoclonal antibodies directed to NHL-30.5 antigen (expressed on poorly differentiated cells), CD13, CD14, CD15, CD33 and CD34 antigens. Expression CD14 correlated with higher leucocyte count, serum lactate dehydrogenase level presentation extramedullary disease. There no strict correlation the French-American-British classification. However, expression associated monocytic subtypes. CD15 mainly expressed M2 M3 subtypes, antigens AUL M1 leukaemias. All patients were treated same intensive induction treatment. Staining by three had prognostic value. complete remission (CR) rates 38% (26/68) NHL-30.5-positive versus 75% (62/77) NHL-30.5-negative (P less than 10(-5), 50% (37/74) CD34-positive 72% (51/71) CD34-negative = 0.007) 70% (77/110) CD15-positive 31% (11/35) CD15-negative 10(-4). shorter survival 10(-3) P 10(-2) respectively), whereas longer 10(-3). In multivariate analysis, antigen, absence high LDH poor survival. CR duration not influenced any factors studied, including expression. These results suggest that leukaemias phenotype have lower response rate