Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.

摘要: Bcl-2, Bcl-xL, CrmA and tetrapeptide ICE inhibitor reduce the extent of necrotic cell death induced by cyanide, which primarily damages mitochondria. Although none them affects drastic decrease in ATP levels Bcl-2 Bcl-xL but not or inhibit cyanide-induced mitochondrial membrane potential. A similar blocking effect is observed on other respiration inhibitors, rotenone antimycin A, apoptotic etoposide calcium ionophore. These results indicate that Bc1-2 protect mitochondria against loss function during both apoptosis at least some forms death. The family proteases act a different step than