Exosome/microvesicle-mediated epigenetic reprogramming of cells

摘要: Microvesicles (MVs) are released by different cell types and may remain in the extracellular space proximity of origin or enter biological fluids. MVs tumor cells detectable patients with cancer their number circulation correlates poor prognosis. Recent studies demonstrated that act as mediator cell-to-cell communication thus ensuring short- long-range exchange information. Due to pleyotropic effects, play a role prothrombotic state associated well development progression. It has been recently shown induce epigenetic changes target transferring genetic This finding suggests stromal talk each other via establish favorable niche promote growth, invasiveness Moreover, contain material under form mRNA microRNA, allow an easy screening for markers offer new diagnostic prognostic review presents overview many actions potential MV-mediated information among biology.