Correlation between exon 3 polymorphism of growth hormone receptor gene and the responses to rhGH therapy
作者： Pengli Bao , Rongxiu Zheng , Yuhui Zhou , Ying Wei , Jing Wang
DOI:
关键词: Short stature 、 Growth hormone receptor 、 Correlation 、 Growth hormone deficiency 、 Retrospective cohort study 、 Idiopathic short stature 、 Biology 、 Endocrinology 、 Internal medicine 、 Genotype 、 Exon
摘要: Objective: To investigate the correlation between exon 3 polymorphism of growth hormone receptor (GHR) gene and responses to recombinant human (rhGH) therapy in children with short stature. Methods: Forty-five deficiency (GHD) (male: 30, female: 15, aged 10.39±2.73 yrs) twenty-five idiopathic stature (ISS) 10, 10.58±2.56 admitted our hospital were included. The GHR was determined using multiple PCR amplification. Treatment duration for each subject at least 12 months. On this basis, we evaluated treatment efficiency rhGH polymorphism, GHD, duration. Results: Significant difference noted velocity (GV) GHD a genotype GHRfl compared those GHRd3 (9.44±2.35 vs. 11.36±2.49, P 5 ng/ml, satisfactory response (P < 0.05). A higher obtained received an early age.
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