Strategies and open questions in solid-phase protein chemical synthesis
作者： Vangelis Agouridas , Vincent Diemer , Oleg Melnyk
DOI: 10.1016/J.CBPA.2020.02.007
关键词: Biophysics 、 Phase (matter) 、 Diffusion 、 Peptide 、 Folding (chemistry) 、 Kinetics 、 Protein biosynthesis 、 Chemistry 、 Protein chemical synthesis
摘要: Abstract The review gives a large overview of the strategies used for protein synthesis by chemoselective peptide segment ligation on solid support. It discusses also important aspects that remain to be explored further develop technology such as role support reactant diffusion rates, kinetics, well folding and functionality proteins attached
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