Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands
作者： Ladislav Šimo , Juraj Koči , Dušan Žitňan , Yoonseong Park
DOI: 10.1371/JOURNAL.PONE.0016158
关键词: Paracrine Communication 、 Dopamine 、 Dopamine receptor 、 Biology 、 Internal medicine 、 Salivary gland 、 Endocrinology 、 Paracrine signalling 、 Cell biology 、 Receptor 、 Dopamine receptor D1 、 Secretion 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Ticks that feed on vertebrate hosts use their salivary secretion, which contains various bioactive components, to manipulate the host's responses. The mechanisms controlling tick gland in this dynamic process are not well understood. We identified D1 receptor activated by dopamine, a potent inducer of secretion ticks. Temporal and spatial expression patterns examined immunohistochemistry reverse transcription polymerase chain reaction suggest dopamine produced basal cells acini is secreted into lumen activates receptors luminal surface lining acini. Therefore, we propose paracrine function mediated at an early phase feeding. molecular pharmacological characterization study provides foundation for understanding functions blood-feeding
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