Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine A, a multi‑target anti‑Alzheimer's molecule

摘要: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by learning and memory impairments. Recent studies have suggested that AD can be induced multiple factors, such as cholinergic system dysfunction β-amyloid (Aβ) neurotoxicity. It was reported 6-bromo-N-propionyltryptamine could treat neurological diseases, including AD. In the present study, 6-bromotryptamine A, derivative of 6-bromo-N-propionyltryptamine, synthesized condensation 2-(6-bromo-1H-indol-3-yl)ethan-1-amine 2-(4-bromophenyl)acetic acid, used potential anti-AD molecule. Furthermore, scopolamine induce impairments memory, widely to establish animal models. The results demonstrated A significantly prevented scopolamine-induced short-term cognitive impairments, revealed various behavioral tests in mice. an acetylcholinesterase (AChE) activity assay directly inhibited AChE activity. Notably, it observed blocked formation Aβ oligomer, evaluated dot blot assay. All these may prevent ability possibly via inhibition blockade oligomer formation.