Effects of (Anti) Androgenic Endocrine Disruptors (DEHP and Butachlor) on Immunoglobulin M (IgM) and Leukocytes Counts of Male Rainbow Trout (Oncorhynchus mykiss).
作者： Sohrab Ahmadivand , Hamid Farahmand , Alireza Mirvaghefi , Soheil Eagderi , Ashkan Zargar
DOI: 10.1007/S00128-015-1503-Y
关键词: Endocrinology 、 Rainbow trout 、 Testosterone 、 Immunoglobulin M 、 Internal medicine 、 Trout 、 Biology 、 Phthalate 、 Butachlor 、 Monocyte 、 Endocrine system
摘要: The effect of two anti-androgenic endocrine disrupting compounds, i.e. the plasticizer di (2-ethylhexyl) phthalate (DEHP) and herbicide butachlor, were evaluated for their effects on immunoglobulin M (IgM) leukocytes in male rainbow trout. Also, plasma testosterone (T) concentration was measured to confirm effects. In first experiment, trout treated with 50 mg/kg (body weight) DEHP intraperitoneally, second one, fish exposed 0.39 mg/L butachlor 10 days. results showed that T concentrations white blood cells significantly lower either or compared control (p 0.05). addition, no significant differences found IgM, eosinophil monocyte parameters treatments (p > 0.05). These confirmed counts can be considered as a novel marker immunotoxicity triggered by (anti) androgenic disruptors.
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