Transgenerational effects of proton beam irradiation on Caenorhabditis elegans germline apoptosis
作者： Hyemin Min , Minhee Sung , Miseol Son , Ichiro Kawasaki , Yhong-Hee Shim
DOI: 10.1016/J.BBRC.2017.06.085
关键词: Histone methyltransferase 、 Genetics 、 Apoptosis 、 Cancer 、 Caenorhabditis elegans 、 Germline 、 Irradiation 、 Caenorhabditis 、 Biology 、 Cell biology 、 Radiation therapy
摘要: When treating cancer using radiation therapy, it is critical to increase patient survival rates and reduce side effects. In this respect, proton beam treatment performs better than other treatments because of its high target specificity. However, complications still remain after treatment. Among them, the risk progeny irradiation their parents a major concern. study, we analyzed transgenerational effects model organism Caenorhabditis. elegans. We found that germline apoptosis increased were sustained transgenerationally. Moreover, identified germline-specific histone methyltransferase component, SET-2, has role in transmitting effect on next generation irradiation.
sci-hub.se 参考文章(29)
Richard P. Levy, Eleanor A. Blakely, William T. Chu, George B. Coutrakon, Eugen B. Hug, Gerhard Kraft, Hirohiko Tsujii, Floyd D. McDaniel, Barney L. Doyle, The Current Status and Future Directions of Heavy Charged Particle Therapy in Medicine APPLICATION OF ACCELERATORS IN RESEARCH AND INDUSTRY: Twentieth International#N#Conference. ,vol. 1099, pp. 410- 425 ,(2009) , 10.1063/1.3120064
J.F. Ward, DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 35, pp. 95- 125 ,(1988) , 10.1016/S0079-6603(08)60611-X
S Brenner, THE GENETICS OF CAENORHABDITIS ELEGANS Genetics. ,vol. 77, pp. 71- 94 ,(1974) , 10.1093/GENETICS/77.1.71
Hyemin Min, Ichiro Kawasaki, Joomi Gong, Yhong-Hee Shim, Caffeine Induces High Expression of cyp-35A Family Genes and Inhibits the Early Larval Development in Caenorhabditis elegans Molecules and Cells. ,vol. 38, pp. 236- 242 ,(2015) , 10.14348/MOLCELLS.2015.2282
Kyong Yun Lee, Insil Yang, Jung-Eun Park, Ok-Ryun Baek, Kee Yang Chung, Hyeon-Sook Koo, Developmental stage- and DNA damage-specific functions of C. elegans FANCD2 Biochemical and Biophysical Research Communications. ,vol. 352, pp. 479- 485 ,(2007) , 10.1016/J.BBRC.2006.11.039
Olga Kovalchuk, Paula Burke, Jill Besplug, Mark Slovack, Jody Filkowski, Igor Pogribny, Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation. Mutation Research. ,vol. 548, pp. 75- 84 ,(2004) , 10.1016/J.MRFMMM.2003.12.016
R.J. Livesay, C.S. Blessinger, T.F. Guzzardo, P.A. Hausladen, Rain-induced increase in background radiation detected by Radiation Portal Monitors. Journal of Environmental Radioactivity. ,vol. 137, pp. 137- 141 ,(2014) , 10.1016/J.JENVRAD.2014.07.010
Sara Andux, Ronald E. Ellis, Apoptosis Maintains Oocyte Quality in Aging Caenorhabditis elegans Females PLoS Genetics. ,vol. 4, pp. e1000295- ,(2008) , 10.1371/JOURNAL.PGEN.1000295
Adeline Buisset-Goussen, Benoit Goussen, Claire Della-Vedova, Simon Galas, Christelle Adam-Guillermin, Catherine Lecomte-Pradines, Effects of chronic gamma irradiation: a multigenerational study using Caenorhabditis elegans. Journal of Environmental Radioactivity. ,vol. 137, pp. 190- 197 ,(2014) , 10.1016/J.JENVRAD.2014.07.014
E Jane Albert Hubbard, David Greenstein, Introduction to the germ line WormBook. pp. 1- 4 ,(2005) , 10.1895/WORMBOOK.1.18.1