Etoposide and Teniposide

摘要: Etoposide and teniposide are epipodophyllotoxins that inhibit topoisomerase II, a ubiquitous enzyme is essential for survival plays critical roles in DNA metabolism, chromosome organization, mitosis (1). act by stabilizing the covalent linkage between II These agents have been studied clinical trials over 25 yr (2, 3), but their contribution to therapy of acute lymphoblastic leukemia (ALL) myeloid (AML) children remains be clearly elucidated. There minor distinctions etoposide teniposide. The latter agent more potent vitro tests cytotoxicity, associated with higher albumin binding, lipophilic, has slightly longer plasma elimination halflife (approx 8 vs 6 h) (4–6). However, these differences do not correlate any therapeutic advantage vivo (7). Randomized studies shown similar levels antitumor activity when used at equitoxic doses (8, 9), current regimens utilize an epipodophyllotoxin employ etoposide. Hence, this chapter, two discussed under assumption they or less interchangeable.