Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats.
作者： M. Niittykoski , J. Nissinen , M. Penttonen , A. Pitkänen
DOI: 10.1016/J.NEUROSCIENCE.2003.11.027
关键词: Internal medicine 、 Temporal lobe 、 Amygdala 、 Neuroscience 、 Epileptogenesis 、 Medicine 、 Status epilepticus 、 Central nervous system 、 Basal (phylogenetics) 、 Basal ganglia 、 Endocrinology 、 Epilepsy
摘要: Abstract The functional consequences of neuronal loss during epileptogenesis in the lateral and basal amygdaloid nuclei are poorly understood. present study tested hypothesis that electrical responsiveness varies different chronically epileptic amygdala. Further, we examined region most prone to seizure initiation. Epileptogenesis was triggered 20 rats by inducing status epilepticus (SE) with stimulation nucleus Electrode-implanted non-stimulated served as controls. occurrence duration spontaneous seizures were monitored video-electroencephalography (EEG) at 8–9 weeks after SE. Thereafter, animals killed extracellular recordings made from slices both amygdalas. In animals, frequency responses reduced compared controls ( P ≤0.05). PP facilitation enhanced =0.001) smaller slopes vivo is associated electrophysiologic alterations vitro .
elsevier.com
sci-hub.se 参考文章(31)
David L. Martin, Richard W. Olsen, Gaba in the nervous system : the view at fifty years Lippincott Williams & Wilkins. ,(2000)
LE White, JL Price, The functional anatomy of limbic status epilepticus in the rat. I. Patterns of 14C-2-deoxyglucose uptake and Fos immunocytochemistry The Journal of Neuroscience. ,vol. 13, pp. 4787- 4809 ,(1993) , 10.1523/JNEUROSCI.13-11-04787.1993
LE White, JL Price, The functional anatomy of limbic status epilepticus in the rat. II. The effects of focal deactivation The Journal of Neuroscience. ,vol. 13, pp. 4810- 4830 ,(1993) , 10.1523/JNEUROSCI.13-11-04810.1993
Masayuki Kobayashi, Paul S. Buckmaster, Reduced Inhibition of Dentate Granule Cells in a Model of Temporal Lobe Epilepsy The Journal of Neuroscience. ,vol. 23, pp. 2440- 2452 ,(2003) , 10.1523/JNEUROSCI.23-06-02440.2003
Bret N Smith, F.Edward Dudek, Enhanced population responses in the basolateral amygdala of kainate-treated, epileptic rats in vitro Neuroscience Letters. ,vol. 222, pp. 1- 4 ,(1997) , 10.1016/S0304-3940(97)13326-2
Masako Isokawa-Akesson, Charles L. Wilson, Thomas L. Babb, Structurally stable burst and synchronized firing in human amygdala neurons: Auto- and cross-correlation analyses in temporal lobe epilepsy Epilepsy Research. ,vol. 1, pp. 17- 34 ,(1987) , 10.1016/0920-1211(87)90047-7
P.S Mangan, C.A Scott, J.M Williamson, E.H Bertram, Aberrant neuronal physiology in the basal nucleus of the amygdala in a model of chronic limbic epilepsy. Neuroscience. ,vol. 101, pp. 377- 391 ,(2000) , 10.1016/S0306-4522(00)00358-4
V Armand, P Hoffmann, M Vergnes, U Heinemann, Epileptiform activity induced by 4-aminopyridine in entorhinal cortex hippocampal slices of rats with a genetically determined absence epilepsy (GAERS) Brain Research. ,vol. 841, pp. 62- 69 ,(1999) , 10.1016/S0006-8993(99)01781-3
Jarkko Tuunanen, Toivo Halonen, Asla Pitkänen, Status epilepticus causes selective regional damage and loss of GABAergic neurons in the rat amygdaloid complex. European Journal of Neuroscience. ,vol. 8, pp. 2711- 2725 ,(1996) , 10.1111/J.1460-9568.1996.TB01566.X
Michael A. Rogawski, Jeffery L. Barker, Effects of 4-aminopyridine on calcium action potentials and calcium current under voltage clamp in spinal neurons Brain Research. ,vol. 280, pp. 180- 185 ,(1983) , 10.1016/0006-8993(83)91190-3