Structurally stable burst and synchronized firing in human amygdala neurons: Auto- and cross-correlation analyses in temporal lobe epilepsy

摘要: Abstract Burst structure and synchronized firing of bursts were studied, in the interictal period, using auto- cross-correlation analyses human amygdala neurons temporal lobe epilepsy patients diagnosed as having a unilateral limbic seizure focus anterior hippocampus and/or amygdala. Satisfactory single unit recordings obtained from chronically implanted microelectrodes 51 neurons, auto-correlation analysis identified 27 where burst firings recurred with regular interspike interval structures (structurally stable burst: S-burst). This structural stability was characteristic only for short burst, or at beginning series repetitive firings, involving 2–5 action potentials. In ‘non-epileptic’ located contralateral to focus, average duration S-burst 15 msec number potentials (spikes) inversely related intervals S-burst, suggesting that endogenous membrane characteristics non-epileptic determine patterns S-burst. contrast, (‘epileptic’), prolonged among epileptic not because occurrence more within but Furthermore, there no relationship between synaptic inputs extracellular environmental factors may affect an intrinsic mechanism generating neurons. Cross-correlation neurons: when two both exhibited S-bursts, either neuron never neither S-bursts. Conversely, rarely fired synchronously; even though they showed The difference pattern S-bursts seems be degree synchrony. Our results provide, first time, direct evidence epileptogenic recorded vivo have unique significant synchronous excitatory interactions, different found non-epileptogenic during period.