MAPK7 Regulates EMT Features and Modulates the Generation of CTCs.

Carsten Sticht, Kolja Freier, Karl Knöpfle, Christa Flechtenmacher, Susanne Pungs, Christof Hofele, Meinhard Hahn, Stefan Joos, Peter Lichter, Activation of MAP kinase signaling through ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC). Neoplasia. ,vol. 10, pp. 462- 470 ,(2008) , 10.1593/NEO.08164

Jean Paul Thiery, Hervé Acloque, Ruby Y.J. Huang, M. Angela Nieto, Epithelial-Mesenchymal Transitions in Development and Disease Cell. ,vol. 139, pp. 871- 890 ,(2009) , 10.1016/J.CELL.2009.11.007

B. Luo, H. W. Cheung, A. Subramanian, T. Sharifnia, M. Okamoto, X. Yang, G. Hinkle, J. S. Boehm, R. Beroukhim, B. A. Weir, C. Mermel, D. A. Barbie, T. Awad, X. Zhou, T. Nguyen, B. Piqani, C. Li, T. R. Golub, M. Meyerson, N. Hacohen, W. C. Hahn, E. S. Lander, D. M. Sabatini, D. E. Root, Highly parallel identification of essential genes in cancer cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 20380- 20385 ,(2008) , 10.1073/PNAS.0810485105

James W. Antoon, Elizabeth C. Martin, Rongye Lai, Virgilo A. Salvo, Yan Tang, Ashley M. Nitzchke, Steven Elliott, Seung Yoon Nam, Wei Xiong, Lyndsay V. Rhodes, Bridgette Collins-Burow, Odile David, Guandi Wang, Bin Shan, Barbara S. Beckman, Kenneth P. Nephew, Matthew E. Burow, MEK5/ERK5 Signaling Suppresses Estrogen Receptor Expression and Promotes Hormone-Independent Tumorigenesis PLoS ONE. ,vol. 8, pp. e69291- ,(2013) , 10.1371/JOURNAL.PONE.0069291

R Nair, D L Roden, W S Teo, A McFarland, S Junankar, S Ye, A Nguyen, J Yang, I Nikolic, M Hui, A Morey, J Shah, A D Pfefferle, J Usary, C Selinger, L A Baker, N Armstrong, M J Cowley, M J Naylor, C J Ormandy, S R Lakhani, J I Herschkowitz, C M Perou, W Kaplan, S A O'Toole, A Swarbrick, c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer Oncogene. ,vol. 33, pp. 3992- 4002 ,(2014) , 10.1038/ONC.2013.368

Jayanta Debnath, Senthil K. Muthuswamy, Joan S. Brugge, Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures Methods. ,vol. 30, pp. 256- 268 ,(2003) , 10.1016/S1046-2023(03)00032-X

M Lombaerts, T van Wezel, K Philippo, J W F Dierssen, R M E Zimmerman, J Oosting, R van Eijk, P H Eilers, B van de Water, C J Cornelisse, A-M Cleton-Jansen, E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. British Journal of Cancer. ,vol. 94, pp. 661- 671 ,(2006) , 10.1038/SJ.BJC.6602996

J. H. Taube, J. I. Herschkowitz, K. Komurov, A. Y. Zhou, S. Gupta, J. Yang, K. Hartwell, T. T. Onder, P. B. Gupta, K. W. Evans, B. G. Hollier, P. T. Ram, E. S. Lander, J. M. Rosen, R. A. Weinberg, S. A. Mani, Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 15449- 15454 ,(2010) , 10.1073/PNAS.1004900107

Soyoung Lim, Astrid Becker, Andreas Zimmer, Jianrong Lu, Reinhard Buettner, Jutta Kirfel, SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0066558

Renate König, Chih-yuan Chiang, Buu P Tu, S Frank Yan, Paul D DeJesus, Angelica Romero, Tobias Bergauer, Anthony Orth, Ute Krueger, Yingyao Zhou, Sumit K Chanda, A probability-based approach for the analysis of large-scale RNAi screens. Nature Methods. ,vol. 4, pp. 847- 849 ,(2007) , 10.1038/NMETH1089