Androgen receptors in rat and human prostate.

摘要: In intact adult rats almost all androgen receptor (AR) sites of the rat ventral prostate (RVP) are occupied by endogenous dihydrotestosterone, and about 80% these nuclear. Nuclear AR disappears rapidly after castration (half-life 3 h). The amount cytosolic does not change within initial 36 h, then markedly decreases during next 2-5 days. An early specific action is a remarkable increase its own receptor. RVP also contains an estradiol (ER) which which, contrary to AR, predominantly localized in cytosol stromal elements. published procedures for steroid receptors grossly underestimate concentrations normal (NHP) hyperplastic (BPH) human prostate. We have recently established reliable method measurement total we found no difference between NHP BPH. BPH progesterone elusive ER. Finally, used immunoglobulins sex hormone binding plasma protein (SBP) demonstration SBP-like immunoreactivity indirect immunofluorescence technique. antigenic material was exclusively cytoplasm epithelial cells.