Prostate Adenocarcinoma: Effects of Castration on in Situ Androgen Uptake by Individual Cell Types
作者： Marguerite C. Lippert , Donald A. Keefer
DOI: 10.1016/S0022-5347(17)43906-1
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摘要: AbstractThe cellular distribution of androgen uptake was investigated in normal prostate and Dunning R3327H tumors Copenhagen rats vivo at different time intervals after castration. Quantitative dry-autoradiography used to demonstrate which cell types have binding, quantify the amount binding per type during initial castration-induced tumor regression subsequent relapse. Regardless castration, stromal nuclei had significantly more 3H-dihydrotestosterone (DHT) labelling than did epithelial (p <.001). On other hand, gland showed 3H-DHT nuclei. Tumor greater DHT any measured or secondary sex organs all times Different responded differently The castration that one day c...
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