Adaptive Evolution of a Stress Response Protein

摘要: Background Some cancers are mediated by an interplay between tissue damage, pathogens and localised innate immune responses, but the mechanisms that underlie these linkages only beginning to be unravelled. Methods Principal Findings Here we identify a strong signature of adaptive evolution on DNA sequence mammalian stress response gene SEP53, member epidermal differentiation complex fused-gene family known for its role in suppressing cancers. The SEP53 appears have been subject type is commonly (though not exclusively) associated with coevolutionary arms races. A similar pattern molecular was evident p53 cancer-suppressing gene. Conclusions Our data thus raises possibility component mucosal/epithelial engaged ongoing interaction pathogen. Although pathogenic mediating known, there number well-known candidates, particular viruses established links carcinoma.