Platelet shape change and cytoskeletal reorganization on polyurethaneureas

摘要: Understanding how platelet activation responses are affected by polymers having varied surface physicochemical properties can lead to improved materials for vascular applications. The in vitro of human platelets were studied upon adherence four polyurethaneureas with different soft segments, as well Biomer, and Formvar. Platelets observed video-enhanced light microscopy (VLM) they adhered polymer films. subsequently prepared high-voltage transmission electron (HVEM) view the cytoskeleton other ultrastructural features. Scanning (SEM) was then used characterize cell morphology survey populations. Shape change cytoskeletal reorganization differed on various surfaces. extent shape related polyurethane energetic properties. While most extensive hydrophilic polar Formvar surface, least a polyethylene oxide segment similar surface-water Therefore than energetics must be involved determining classes polymers. HVEM also showed that proceeded completion only Polyurethane adherent platelets, although appearing fully spread SEM or VLM, never exhibited complete reorganization.