Protective effect of harmaline and harmalol against dopamine‐ and 6‐hydroxydopamine‐induced oxidative damage of brain mitochondria and synaptosomes, and viability loss of PC12 cells
作者： Dong Hyun Kim , Yoon Young Jang , Eun Sook Han , Chung Soo Lee
DOI: 10.1046/J.0953-816X.2001.01563.X
关键词: Harmine 、 Harmaline 、 Superoxide dismutase 、 Pharmacology 、 Oxidative stress 、 Harmalol 、 Mitochondrion 、 Viability assay 、 Chemistry 、 Biochemistry 、 Reactive oxygen species
摘要: The present study elucidated the protective effect of beta-carbolines (harmaline, harmalol and harmine) against oxidative damage brain mitochondria, synaptosomes PC12 cells induced by either dopamine or 6-hydroxydopamine. Harmaline, antioxidant enzymes (superoxide dismutase/SOD catalase) decreased alteration mitochondrial swelling membrane potential 200 microM 100 Deprenyl attenuated dopamine-induced dysfunction but did not reduce While inhibited electron flow in they enhance depressant catecholamines. beta-Carbolines reversed depression synaptosomal Ca2+ uptake 10 compounds catecholamine-induced thioredoxin reductase inhibition, thiol oxidation carbonyl formation mitochondria synaptosomes. reactive species-induced deoxyribose degradation. Harmaline reduced loss transmembrane cell viability cells. alone show a significant cytotoxic on results suggest that may attenuate dopamine- 6-hydroxydopamine-induced functions, cells, scavenging action oxygen species inhibition oxidation.
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