Evaluation of antidepressant-like effect of hydroalcoholic extract of Passiflora incarnata in animal models of depression in male mice
作者： Nima Jafarpoor , Majid Asadi-Samani , Mir Hadi Khayatnouri , Saeid Abbasi-Maleki
DOI:
关键词: Fluoxetine 、 Traditional medicine 、 Saline 、 Imipramine 、 Passiflora incarnata 、 Tail suspension test 、 Sedative 、 Behavioural despair test 、 Animal models of depression 、 Medicine
摘要: Introduction: Passiflora incarnata (PI) is one of the commonest herbal anti-anxiety and sedative agents. The aim present study was to investigate antidepressant effect hydroalcoholic extract PI in forced swim test (FST) tail suspension (TST) male mice. Methods: In this experimental study, 48 mice were randomly divided into 6 groups 8: Negative positive control received normal saline (10 ml/kg), fluoxetine (20 mg/kg) imipramine (30 mg/kg), respectively treatment extracts (200, 400 800 mg/kg). Immobility, swimming climbing behaviors recorded during 6-min. Results: All doses compared group significantly reduced duration immobility time both two tests (p<0.001). Also, these increased (p<0.001) without significant change time. Conclusion: has considerable antidepressant-like animal models depression. However, further studies are needed determine its exact mechanism action.
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