Depression during menopausal transition: a review of treatment strategies and pathophysiological correlates.

摘要: It has long been recognized that women are at a higher risk than men to develop depression and such is particularly associated with reproductive cycle events. Recent long-term, prospective studies have demonstrated the transition menopause for new onset recurrent depression. A number of biological environmental factors independent predictors in this population, including presence hot flushes, sleep disturbance, history severe premenstrual syndrome or postpartum blues, ethnicity, stressful life events, past depression, body mass index, socioeconomic status use hormones antidepressants. Accumulated evidence suggests ovarian modulate serotonin noradrenaline neurotransmission, process may be underlying pathophysiological processes involved emergence depressive symptoms during periods hormonal fluctuation biologically predisposed subpopulations. Transdermal estradiol serotonergic noradrenergic antidepressants efficacious treatment vasomotor symptomatic, midlife women. The identification individuals whom might menopausal could guide preventive strategies population.