Long-Term Effects of Excess Protein and Phosphorus on Bone Homeostasis in Adult Mice

摘要: In adult human subjects, an interaction between dietary protein and phosphorus has been reported, in which the hypercalciuric effect of excess is counteracted by hypocalciuric phosphorus, with restoration calcium balance. rodents, bone homeostasis maintained over a wide range intakes, whereas high diets cause loss, despite their effect, as result overriding increase excretion endogenous fecal calcium. The present study was designed to determine whether there respect mice. Four-month-old 45Ca-labeled B6D2F1 female mice were fed for 52 weeks following (in percent): control, Ca, 0.6; P, 0.3; protein, 15; Ca. 1.2; 30; P + 30. Urinary persistently increased group, depressed group transiently group. Excess prevented phosphorus-induced kidney calcinosis. 45Ca loss groups, but not There significant decreases mass femurs tibias both no intake. These results show that sensitive these nutrients effects on bone.