Effects of Sex on Intra-Individual Variance in Urinary Solutes in Stone-Formers Collected from a Single Clinical Laboratory

摘要: Background/Aims Our work in a rodent model of urinary calcium suggests genetic and gender effects on increased residual variability urine chemistries. Based these findings, we hypothesized that sex would similarly be associated with variation human solutes. Sex-related residuals might affect the establishment physiological baselines error medical assays. Methods We tested chemistry by estimating coefficients (CV) for solutes paired sequential 24-h urines (≤72 hour interval) 6,758 females 9,024 males aged 16–80 submitted to clinical laboratory. Results Females had higher CVs than phosphorus overall at False Discovery Rate (P 0.3). Males citrate (P<0.01) from ages 16–45 56–80, suggesting an extant oestral cycle variance. Conclusions findings indicate variance excretion including citrate; differences CV reflect dietary lability, fidelity reporting or differentiation renal solute consistency. Such effect could complicate analysis addition random phenotypic assays. Renal require explicit incorporation heterogeneity among factorial effects, particular.