Pathways of Glucose Utilization in Mammary Tissue

摘要: Although the most important method of glucose catabolism is undoubtedly by degradation via classical Embden-Meyerhof-Parnas glycolytic pathway followed oxidation triose tricarboxylic acid cycle, existence alternative routes now certain and these can, indeed, operate exclusively in some micro-organisms. Of pathways, that originally discovered Warburg yeast extracts generally referred to as pentose phosphate pathway. The pioneer work Warburg, Lipmann Dickens has been reviewed (1953). Renewed interest this during last few years established its widespread occurrence animal tissues, plants Precise evidence for cyclic nature characterization intermediates enzyme reactions involved can be attributed chiefly Horecker Racker their co-workers (Horecker & Mehler 1955; Gunsalas, Wood 1957). This somewhat complex cycle shown figure 31. three 6-phosphate molecules required each turn two are regenerated from catalyzed transketolase transaldolase. All reactions, like those route, localized essentially soluble fraction cell homogenates (Glock McLean 1954; Newburgh Cheldelin 1956).