The metabolism of estrogens in normal women after pulse injections of 3H-estradiol and 3H-estrone.

摘要: ABSTRACT 3H-estradiol was administered as a single pulse to 7 normal women between days 5–7 of their menstrual cycle. The disappearance from the blood 3H free estradiol in all subjects could be best described function which sum 3 exponentials. mean (± se) initial volume distribution (V1) 10.9 ±1.1 1. metabolic clearance rate (MCR2) 740 ± 50 1/day/m2, production 80 11 μg/day. Estradiol contributed 27 7% estrone. 3H-estrone 5 In estrone 2 For V1 32.4 6.5 MCR1 1120 1/day/m2; 101 13 Estrone m...